| Year: | 1964 |
| Team: | East Texas State Lions |
| Sport: | football |
| Conference: | Lone Star Conference |
| Short Conf: | LSC |
| Record: | 2–7 |
| Conf Record: | 1–5 |
| Head Coach: | Ernest Hawkins |
| Hc Year: | 1st |
| Stadium: | Memorial Stadium |
The 1964 East Texas State Lions football team represented East Texas State College—now known as Texas A&M University–Commerce—as a member of the Lone Star Conference (LSC) during the 1964 NAIA football season. Led by first-year head coach Ernest Hawkins, the Lions compiled an overall record of 2–7 with a mark of 1–5 in conference play, placing sixth in the LSC. Hawkins had taken over the program after the sudden death of Jules V. Sikes in the spring of 1964. The team their home games at Memorial Stadium in Commerce, Texas.