| Competition: | Primera División |
| Season: | 1964–65 |
| Winners: | Real Madrid (11th title) |
| Relegated: | Murcia Levante Oviedo Deportivo La Coruña |
| Continentalcup1 Qualifiers: | Real Madrid |
| Continentalcup2: | Cup Winners' Cup |
| Continentalcup2 Qualifiers: | Atlético Madrid |
| League Topscorer: | Cayetano Ré (26 goals) |
| Biggest Home Win: | |
| Highest Scoring: | |
| Matches: | 240 |
| Total Goals: | 659 |
| Prevseason: | 1963–64 |
| Nextseason: | 1965–66 |
The 1964–65 La Liga was the 34th season since its establishment. The season started on September 13, 1964, and finished on April 18, 1965.
| Team | Home city | Stadium | |
|---|---|---|---|
| Barcelona | Nou Camp | ||
| El Arcángel | |||
| Riazor | |||
| Sarrià | |||
| Insular | |||
| Vallejo | |||
| La Condomina | |||
| Oviedo | |||
| Real Betis | Benito Villamarín | ||
| Real Madrid | |||
| Seville | |||
| Valencia | |||
| Zaragoza | La Romareda |
|}
| Rank | Goalscorer | Goal | Team |
|---|---|---|---|
| 1 | Cayetano Ré | 25 | Barcelona |
| 2 |  Waldo | 21 | Valencia CF |
| 3 |  Luis Aragonés | 19 | Atlético Madrid |
| 4 | Ramón Grosso | 17 | Real Madrid |
| 5 | Fernando Ansola | 14 | Real Betis |
 Juan Seminario | 14 | Barcelona |