| Competition: | Campeonato Nacional de Fútbol Profesional |
| Dates: | 27 May 1961 – 5 January 1962 |
| Winners: | Universidad Católica (3rd title) |
| Relegated: | none |
| Matches: | 184 |
| Total Goals: | 684 |
| Continentalcup1: | Copa de Campeones |
| Continentalcup1 Qualifiers: | Universidad Católica |
| League Topscorer: | Carlos Campos (24) Honorino Landa (24) |
| Highest Attendance: | 54,811 |
| Attendance: | 1,193,908 |
| Average Attendance: | 6,488 |
| Prevseason: | 1960 |
| Nextseason: | 1962 |
The 1961 Campeonato Nacional de Fútbol Profesional, was the 29th season of top-flight football in Chile. Universidad Católica won their third title following a 3–2 win against Universidad de Chile in the championship play-off on 5 January 1962, also qualifying for the 1962 Copa de Campeones.
| Name | Team | Goals | |
|---|---|---|---|
| Carlos Campos | Universidad de Chile | 24 | |
| Honorino Landa | Unión Española | 24 |