| Year: | 1960 |
| Team: | Mississippi Southern Southerners |
| Sport: | football |
| Conference: | Independent |
| Record: | 6–4 |
| Head Coach: | Thad Vann |
| Hc Year: | 12th |
| Stadium: | Faulkner Field |
The 1960 Mississippi Southern Southerners football team was an American football team that represented Mississippi Southern College (now known as the University of Southern Mississippi) as an independent during the 1960 college football season. In their twelfth year under head coach Thad Vann, the team compiled a 6–4 record.