| Competition: | Serie A |
| Season: | 1960–61 |
| Winners: | Juventus 12th title |
| Relegated: | Bari Napoli Lazio |
| Continentalcup1: | European Cup |
| Continentalcup1 Qualifiers: | Juventus |
| Continentalcup3: | Inter-Cities Fairs Cup |
| Continentalcup3 Qualifiers: | Milan Internazionale Roma |
| Continentalcup2: | Cup Winners' Cup |
| Continentalcup2 Qualifiers: | Fiorentina |
| League Topscorer: | Sergio Brighenti (27 goals) |
| Matches: | 306 |
| Total Goals: | 814 |
| Prevseason: | 1959–60 |
| Nextseason: | 1961–62 |
The 1960–61 Serie A season was won by Juventus.
Torino, Lecco and Catania had been promoted from Serie B.
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| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 |  Sergio Brighenti | Sampdoria | 27 |
| 2 |  Omar Sívori | Juventus | 25 |
| 3 |  José Altafini | Milan | 21 |
| 4 | Pedro Manfredini | Roma | 20 |
| 5 | Aurelio Milani | Padova | 18 |
| 6 | Eddie Firmani | Internazionale | 16 |
| 7 | John Charles | Juventus | 15 |
| 8 | Bruno Mora | Sampdoria, Juventus | 14 |
 Kurt Hamrin | Fiorentina | ||
| Lorenzo Bettini | Udinese | ||
| 11 | Santiago Vernazza | Milan | 13 |
| Oscar Massei | SPAL | ||
| Bruno Nicolè | Juventus | ||
| Francisco Lojacono | Roma | ||
| 15 | Adelmo Prenna | Catania | 11 |
| Luís Vinício | Bologna | ||
| Orlando Rozzoni | Lazio | ||
| Oliviero Conti | Vicenza |