The 1960–61 Southern Football League season was the 58th in the history of the league, an English football competition.
Oxford United won the championship, whilst Kettering Town, Cambridge United, Bexleyheath & Welling and Merthyr Tydfil were all promoted to the Premier Division. Ten Southern League clubs applied to join the Football League at the end of the season, but none were successful.
The Premier Division consisted of 22 clubs, including 18 clubs from the previous season and four new clubs, promoted from Division One:
| Competition: | Southern Football League Premier Division |
| Season: | 1960–61 |
| Winners: | Oxford United |
| Relegated: | Dartford Hastings United Wisbech Town |
| Matches: | 462 |
| Total Goals: | 1697 |
| Prevseason: | 1959–60 |
| Nextseason: | 1961–62 |
Division One consisted of 21 clubs, including 16 clubs from the previous season and five new clubs:
| Competition: | Southern Football League Division One |
| Season: | 1960–61 |
| Winners: | Kettering Town |
| Promoted: | Kettering Town Cambridge United Bexleyheath & Welling Merthyr Tydfil |
| Matches: | 420 |
| Total Goals: | 1513 |
| Prevseason: | 1959–60 |
| Nextseason: | 1961–62 |
Ten Southern League clubs (including Bexleyheath & Welling and Kettering Town from Division One) applied for election to the Football League. However, all four League clubs were re-elected.[1]