| Year: | 1959 |
| Team: | Oklahoma State Cowboys |
| Sport: | baseball |
| Conference: | Big Eight Conference |
| Short Conf: | Big Eight |
| Record: | 27-5 |
| Conf Record: | 17-3 |
| Cbrank: | 1 |
| Head Coach: | Toby Greene (16th year) |
| Champion: | National champions Big Eight champions |
The 1959 Oklahoma State Cowboys baseball team represented the Oklahoma State University in the 1959 NCAA University Division baseball season. The team was coached by Toby Greene in his 16th season at Oklahoma State.
The Cowboys won the College World Series, defeating the Arizona Wildcats in the championship game.
! style="background:black;color:white;"| Regular season|-|- align="center" bgcolor="ddffdd"| March 18 || at || 9-3 || 1–0 || –|- align="center" bgcolor="ffdddd"| March 19 || at Rice || 5-6 || 1–1 || –|- align="center" bgcolor="ddffdd"| March 20 || at || 7-2 || 2–1 || –|- align="center" bgcolor="ddffdd"| March 21 || at Houston || 7-4 || 3–1 || –|-|- align="center" bgcolor="ddffdd"| April 10 || || 9-0 || 4–1 || 1-0|- align="center" bgcolor="ddffdd"| April 11 || Kansas || 13-2 || 5–1 || 2-0|- align="center" bgcolor="ddffdd"| April 11 || Kansas || 6-0 || 6–1 || 3-0|- align="center" bgcolor="ddffdd"| April 20 || at || 9-3 || 7–1 || 4-0|- align="center" bgcolor="ddffdd"| April 20 || at Oklahoma || 8-1 || 8–1 || 5-0|- align="center" bgcolor="ddffdd"| April 21 || at Oklahoma || 6-5 || 9–1 || 6-0|- align="center" bgcolor="ddffdd"| April 24 || || 19-1 || 10–1 || 7-0|- align="center" bgcolor="ddffdd"| April 25 || Kansas State || 15-0 || 11–1 || 8-0|- align="center" bgcolor="ddffdd"| April 25 || Kansas State || 8-3 || 12–1 || 9-0|-|- align="center" bgcolor="ffdddd"| May 1 || at || 2-7 || 12–2 || 9-1|- align="center" bgcolor="ddffdd"| May 2 || at Nebraska || 4-1 || 13–2 || 10-1|- align="center" bgcolor="ddffdd"| May 2 || at Nebraska || 5-1 || 14–2 || 11-1|- align="center" bgcolor="ddffdd"| May 8 || at || 10-2 || 15–2 || 12-1|- align="center" bgcolor="ddffdd"| May 9 || at Colorado || 6-5 || 16–2 || 13-1|- align="center" bgcolor="ddffdd"| May 9 || at Colorado || 7-2 || 17–2 || 14-1|- align="center" bgcolor="ffdddd"| May 15 || || 1-4 || 17–3 || 14-2|- align="center" bgcolor="ffdddd"| May 16 || Iowa State || 6-9 || 17–4 || 14-3|- align="center" bgcolor="ddffdd"| May 16 || Iowa State || 3-0 || 18–4 || 15-3|- align="center" bgcolor="ddffdd"| May 22 || || 1-0 || 19–4 || 16-3|- align="center" bgcolor="ddffdd"| May 23 || Missouri || 2-1 || 20–4 || 17-3|-|-! style="background:black;color:white;"| Post-season|-|- align="center" bgcolor="ddffdd"| May 29 || vs. || 7-6 || 21–4|- align="center" bgcolor="ddffdd"| May 30 || vs. Bradley || 6-2 || 22–4|-|- align="center" bgcolor="ddffdd"| June 12 || vs. Western Michigan || Rosenblatt Stadium || 10–2 || 23–4|- align="center" bgcolor="ddffdd"| June 14 || vs. Penn State || Rosenblatt Stadium || 10–6 || 24–4|- align="center" bgcolor="ffdddd"| June 15 || vs. Arizona || Rosenblatt Stadium || 3–5 || 24–5|- align="center" bgcolor="ddffdd"| June 16 || vs. Penn State || Rosenblatt Stadium || 4–3 || 25–5|- align="center" bgcolor="ddffdd"| June 17 || vs. || Rosenblatt Stadium || 4–0 || 26–5|- align="center" bgcolor="ddffdd"| June 18 || vs. Arizona || Rosenblatt Stadium || 5–3 || 27–5|-