| Year: | 1959 |
| Team: | Oklahoma Sooners |
| Sport: | football |
| Conference: | Big Seven Conference |
| Short Conf: | Big 7 |
| Coachrank: | 15 |
| Aprank: | 15 |
| Record: | 7–3 |
| Conf Record: | 5–1 |
| Head Coach: | Bud Wilkinson |
| Hc Year: | 13th |
| Captain: | Bobby Boyd |
| Captain2: | Gilmer Lewis |
| Stadium: | Oklahoma Memorial Stadium |
| Champion: | Big 7 champion |
The 1959 Oklahoma Sooners football team represented the University of Oklahoma during the 1959 college football season. They played their home games at Oklahoma Memorial Stadium and competed as members of the Big Seven Conference. They were coached by head coach Bud Wilkinson.
See also: 1959 NCAA University Division football rankings.
The following players were drafted into the National Football League following the season.[2]
| 2 | 19 | Prentice Gautt | Running back | Cleveland Browns | |
| 10 | 119 | Bobby Boyd | Defensive back | Baltimore Colts | |
| 20 | 233 | Gilmer Lewis | Tackle | Green Bay Packers |