| Year: | 1959 |
| Team: | Mississippi Southern Southerners |
| Sport: | football |
| Conference: | Independent |
| Record: | 6–4 |
| Head Coach: | Thad Vann |
| Hc Year: | 11th |
| Stadium: | Faulkner Field Ladd Stadium |
The 1959 Mississippi Southern Southerners football team was an American football team that represented Mississippi Southern College (now known as the University of Southern Mississippi) as an independent during the 1959 college football season. In their eleventh year under head coach Thad Vann, the team compiled a 6–4 record.