| Year: | 1959 |
| Team: | Duke Blue Devils |
| Sport: | football |
| Conference: | Atlantic Coast Conference |
| Short Conf: | ACC |
| Record: | 4–6 |
| Conf Record: | 2–3 |
| Head Coach: | William D. Murray |
| Hc Year: | 9th |
| Mvp: | Mike McGee |
| Captain: | Mike McGee |
| Stadium: | Duke Stadium |
The 1959 Duke Blue Devils football team was an American football team that represented Duke University as a member of the Atlantic Coast Conference (ACC) during the 1959 college football season. In their ninth year under head coach William D. Murray, the Blue Devils complied an overall record of 4–6, with a conference record of 2–3, and finished sixth in the ACC.