| Competition: | Serie A |
| Winners: | Juventus 11th title |
| Season: | 1959–60 |
| Relegated: | Palermo Alessandria Genoa |
| Continentalcup1: | European Cup |
| Continentalcup1 Qualifiers: | Juventus |
| Continentalcup3: | Inter-Cities Fairs Cup |
| Continentalcup3 Qualifiers: | Internazionale Roma |
| Continentalcup2: | Cup Winners' Cup |
| Continentalcup2 Qualifiers: | Fiorentina |
| League Topscorer: | Omar Sivori (28 goals) |
| Matches: | 306 |
| Total Goals: | 792 |
| Prevseason: | 1958–59 |
| Nextseason: | 1960–61 |
The 1959–60 Serie A season was won by Juventus.
Atalanta and Palermo had been promoted from Serie B.
A modern professional structure was introduced, together with a third relegation.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 |   Omar Sívori | Juventus | 28 |
| 2 |  Kurt Hamrin | Fiorentina | 26 |
| 3 | John Charles | Juventus | 23 |
| 4 | Sergio Brighenti | Padova | 21 |
| 5 |  José Altafini | Milan | 20 |
| 6 | Pedro Manfredini | Roma | 16 |
| 7 | Lorenzo Bettini | Udinese | 14 |
| Gino Pivatelli | Bologna | ||
| Paolo Erba | Bari | ||
| 10 | Arne Selmosson | Roma | 13 |
| Orlando Rozzoni | Lazio | ||
| 12 | Mario Tortul | Padova | 12 |
| Eddie Firmani | Internazionale | ||
| 14 | Antonio Valentín Angelillo | Internazionale | 11 |
| Bengt Lindskog | Internazionale | ||
| Egidio Morbello | SPAL | ||
| Oliviero Conti | Vicenza |