| Season: | 1959–60 |
| Competition: | Maltese First Division |
| Winners: | Valletta F.C. (7th title) |
| Relegated: | Birkirkara F.C. |
| Matches: | 56 |
| Total Goals: | 183 |
| Prevseason: | 1958–59 |
| Nextseason: | 1960–61 |
The 1959–60 Maltese First Division was the 45th season of top-tier football in Malta. It was contested by 8 teams, and Valletta F.C. won the championship.