| Election Name: | 1958 United States Senate election in Wyoming |
| Country: | Wyoming |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1952 United States Senate election in Wyoming |
| Previous Year: | 1952 |
| Next Election: | 1964 United States Senate election in Wyoming |
| Next Year: | 1964 |
| Election Date: | November 4, 1958 |
| Image1: | Gale W. McGee.jpg |
| Nominee1: | Gale W. McGee |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 58,035 |
| Percentage1: | 50.84% |
| Nominee2: | Frank A. Barrett |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 56,122 |
| Percentage2: | 49.16% |
| Map Size: | 255px |
| U.S. Senator | |
| Before Election: | Frank A. Barrett |
| Before Party: | Republican Party (United States) |
| After Election: | Gale W. McGee |
| After Party: | Democratic Party (United States) |
The 1958 United States Senate election in Wyoming took place November 4, 1958. Incumbent Republican Senator Frank A. Barrett ran for re-election to his second term. He was challenged by Gale W. McGee, a University of Wyoming professor and the Democratic nominee. Despite the state's strong Republican lean, McGee ran an energetic campaign against Barrett, earning the support of the national Democratic establishment. McGee ultimately narrowly upset Barrett, winning 51% of the vote to Barrett's 49%.