| Year: | 1958 |
| Team: | Mississippi Southern Southerners |
| Sport: | football |
| Conference: | Independent |
| Record: | 9–0 |
| Head Coach: | Thad Vann |
| Hc Year: | 10th |
| Stadium: | Faulkner Field Ladd Stadium |
| Champion: | UPI small college national champion |
The 1958 Mississippi Southern Southerners football team was an American football team that represented Mississippi Southern College (now known as the University of Southern Mississippi) as an independent during the 1958 college football season. In their tenth year under head coach Thad Vann, the team compiled a 9–0 record and finished as UPI small college national champion.