| Year: | 1957 |
| Team: | Cal Poly Mustangs |
| Sport: | football |
| Conference: | California Collegiate Athletic Association |
| Short Conf: | CCAA |
| Record: | 8–1 |
| Conf Record: | 3–0 |
| Head Coach: | LeRoy Hughes |
| Hc Year: | 8th |
| Stadium: | Mustang Stadium |
The 1957 Cal Poly Mustangs football team represented California Polytechnic State College—now known as California Polytechnic State University, San Luis Obispo—as a member of the California Collegiate Athletic Association (CCAA) during the 1957 college football season. Led by eighth-year head coach LeRoy Hughes, Cal Poly compiled an overall record of 8–1 with a mark of 3–0 in conference play, placing first in the CCAA, although no conference champion was recognized. The team outscored its opponents 210 to 108 for the season. The Mustangs played home games at Mustang Stadium in San Luis Obispo, California.
The following were selected in the 1958 NFL draft.[3]
| Player | Position | Round | Overall | NFL team | |
| Tackle | 21 | 244 | Philadelphia Eagles |