| Year: | 1954 |
| Team: | Mississippi Southern Southerners |
| Sport: | football |
| Conference: | Independent |
| Record: | 6–4 |
| Head Coach: | Thad Vann |
| Hc Year: | 6th |
| Stadium: | Faulkner Field |
The 1954 Mississippi Southern Southerners football team was an American football team that represented Mississippi Southern College (now known as the University of Southern Mississippi) as an independent during the 1954 college football season. In their sixth year under head coach Thad Vann, the team compiled a 6–4 record.