| Election Name: | 1952 United States Senate election in Wyoming |
| Country: | Wyoming |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1946 United States Senate election in Wyoming |
| Previous Year: | 1946 |
| Next Election: | 1958 United States Senate election in Wyoming |
| Next Year: | 1958 |
| Election Date: | November 4, 1952 |
| Image1: | Frank Barrett.jpg |
| Nominee1: | Frank A. Barrett |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 67,176 |
| Percentage1: | 51.64% |
| Nominee2: | Joseph C. O'Mahoney |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 62,921 |
| Percentage2: | 48.36% |
| Map Size: | 255px |
| U.S. Senator | |
| Before Election: | Joseph C. O'Mahoney |
| Before Party: | Democratic Party (United States) |
| After Election: | Frank A. Barrett |
| After Party: | Republican Party (United States) |
The 1952 United States Senate election in Wyoming took place November 4, 1952. Incumbent Democratic senator Joseph C. O'Mahoney ran for his fourth consecutive term. He faced a strong challenge from Republican governor Frank A. Barrett, and faced difficult headwinds as Dwight D. Eisenhower, the Republican nominee for president, was winning Wyoming in a landslide over Democratic nominee Adlai Stevenson. Despite his history of strong performances in the increasingly conservative state, however, O'Mahoney was unable to replicate it, and narrowly lost to Barrett. However, O'Mahoney would return to the Senate less than two years later; following the death of Senator Lester C. Hunt, he was elected to the Senate once again in the 1954 election.