| Election Name: | 1952 United States Senate election in Missouri |
| Country: | Missouri |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1946 United States Senate election in Missouri |
| Previous Year: | 1946 |
| Next Election: | 1958 United States Senate election in Missouri |
| Next Year: | 1958 |
| Election Date: | November 4, 1952 |
| Image1: | File:Portrait of W. Stuart Symington 97-1844.jpg |
| Nominee1: | Stuart Symington |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 1,008,521 |
| Percentage1: | 53.99% |
| Nominee2: | James P. Kem |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 858,170 |
| Percentage2: | 45.94% |
| Map Size: | 270px |
| U.S. Senator | |
| Before Election: | James P. Kem |
| Before Party: | Republican Party (United States) |
| After Election: | Stuart Symington |
| After Party: | Democratic Party (United States) |
The 1952 United States Senate election in Missouri was held on November 4, 1952.
Incumbent Republican Senator James P. Kem ran for re-election to a second term in office, but was defeated by Secretary of the Air Force Stuart Symington.