| Election Name: | 1952 United States Senate election in Maine |
| Country: | Maine |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1946 United States Senate election in Maine |
| Previous Year: | 1946 |
| Next Election: | 1958 United States Senate election in Maine |
| Next Year: | 1958 |
| Election Date: | September 8, 1952 |
| Image1: | Frederick George Payne.jpg |
| Nominee1: | Frederick G. Payne |
| Party1: | Republican Party (US) |
| Popular Vote1: | 139,205 |
| Percentage1: | 58.70% |
| Nominee2: | Roger P. Dube |
| Party2: | Democratic Party (US) |
| Popular Vote2: | 82,665 |
| Percentage2: | 34.86% |
| Image3: | 3x4.svg |
| Nominee3: | Earl S. Grant |
| Party3: | Independent Democratic |
| Popular Vote3: | 15,294 |
| Percentage3: | 6.45% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Party: | Republican Party (US) |
| After Party: | Democratic Party (US) |
The 1952 United States Senate election in Maine was held on September 8, 1952.
Incumbent Republican Senator Owen Brewster ran for re-election to a third term, but lost the Republican primary to Governor of Maine Frederick Payne. Payne easily won the general election against two Democratic opponents, party nominee Roger Dube and independent Democrat Earl Grant.
Payne's campaign was encouraged and partly funded by billionaire Howard Hughes, who sought to end Brewster's political career over the investigation of Hughes's Trans World Airlines for war profiteering.[1]
Payne's victory may also have been aided by Brewster's connections to McCarthyism.