| Competition: | Serie A |
| Season: | 1952–53 |
| Winners: | Internazionale 6th title |
| Relegated: | Como Pro Patria |
| League Topscorer: | Gunnar Nordahl (26 goals) |
| Matches: | 306 |
| Total Goals: | 830 |
| Prevseason: | 1951–52 |
| Nextseason: | 1953–54 |
The 1952–53 Serie A season was won by Internazionale.
Roma had been promoted from Serie B.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 |  Gunnar Nordahl | Milan | 26 |
| 2 | John Hansen | Juventus | 22 |
| 3 | Poul Aage Rasmussen | Atalanta | 19 |
| 4 |  Giancarlo Bacci | Bologna | 18 |
| 5 | Pasquale Vivolo | Juventus | 16 |
| 6 | István Nyers | Internazionale | 15 |
| 7 | Giancarlo Vitali | Napoli | 14 |
| Hasse Jeppson | Napoli | ||
| Carlo Galli | Roma | ||
| 10 | Quinto Bertoloni | Pro Patria | 13 |
| Renzo Burini | Milan | ||
| Marco Savioni | Novara | ||
| 13 | Benito Lorenzi | Internazionale | 12 |
| 14 | Karl Aage Præst | Juventus | 10 |
| István Mike Mayer | Bologna | ||
| Sergio Sega | SPAL |