| Year: | 1951 |
| Team: | Mississippi Southern Southerners |
| Sport: | football |
| Conference: | Gulf States Conference |
| Short Conf: | GSC |
| Record: | 6–5 |
| Conf Record: | 4–0 |
| Head Coach: | Thad Vann |
| Hc Year: | 3rd |
| Stadium: | Faulkner Field |
| Champion: | GSC champion |
The 1951 Mississippi Southern Southerners football team was an American football team that represented Mississippi Southern College (now known as the University of Southern Mississippi) as a member of the Gulf States Conference during the 1951 college football season. In their third year under head coach Thad Vann, the team compiled a 6–5 record.