| Year: | 1951 |
| Team: | Louisville Cardinals |
| Sport: | football |
| Conference: | Independent |
| Record: | 5–4 |
| Head Coach: | Frank Camp |
| Hc Year: | 6th |
| Stadium: | duPont Manual Stadium |
The 1951 Louisville Cardinals football team represented the University of Louisville as an independent during the 1951 college football season. In their sixth season under head coach Frank Camp, the Cardinals compiled a 5–4 record. Future National Football League (NFL) quarterback Johnny Unitas was in his freshman year on the team.
| Player | Position | Round | Pick | NFL club |
| John Brewer | Back | 28 | 329 | Philadelphia Eagles |