| Election Name: | 1950 United States Senate election in Pennsylvania |
| Country: | Pennsylvania |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1944 United States Senate election in Pennsylvania |
| Previous Year: | 1944 |
| Next Election: | 1956 United States Senate election in Pennsylvania |
| Next Year: | 1956 |
| Election Date: | November 7, 1950 |
| Image1: | James Henderson Duff.jpg |
| Nominee1: | James H. Duff |
| Party1: | Republican Party (US) |
| Popular Vote1: | 1,820,400 |
| Percentage1: | 51.30% |
| Nominee2: | Francis J. Myers |
| Party2: | Democratic Party (US) |
| Popular Vote2: | 1,694,076 |
| Percentage2: | 47.74% |
| Map Size: | 260px |
| U.S. Senator | |
| Before Election: | Francis J. Myers |
| Before Party: | Democratic Party (US) |
| After Election: | James H. Duff |
| After Party: | Republican Party (US) |
The 1950 United States Senate election in Pennsylvania was held on November 7, 1950. Incumbent Democratic U.S. Senator Francis J. Myers sought re-election, but was defeated by Republican nominee James H. Duff. As of, this is the last time that Lycoming County voted Democratic in a Senate election.