Fifth-seeded Frank Sedgman defeated Ken McGregor 6–3, 6–4, 4–6, 6–1 in the final to win the men's singles tennis title at the 1950 Australian Championships.
The seeded players are listed below. Frank Sedgman is the champion; others show the round in which they were eliminated.
Jaroslav Drobný (third round)
John Bromwich (quarterfinals) Bill Sidwell (semifinals) Frank Sedgman (champion) George Worthington (quarterfinals) Colin Long (quarterfinals) Mervyn Rose (quarterfinals)