| Season: | 1950–51 |
| Competition: | Maltese First Division |
| Winners: | Floriana F.C. (14th title) |
| Relegated: | St. Andrews F.C. |
| Matches: | 56 |
| Total Goals: | 189 |
| Prevseason: | 1949–50 |
| Nextseason: | 1951–52 |
The 1950–51 Maltese First Division was the 36th season of top-tier football in Malta. It was contested by 8 teams, and Floriana F.C. won the championship.