The 1950–51 Macedonian Republic League was the seventh since its establishment. Rabotnik Bitola won their second championship title.
| Club | City | |
|---|---|---|
| Borec | Kumanovo | |
| Bregalnica | Shtip | |
| Crvena Dzvezda | Veles | |
| Kozhuf | Gevgelija | |
| Ohrid | Ohrid | |
| 11 Oktomvri | Kumanovo | |
| Pitu Guli | Krushevo | |
| Pobeda | Prilep | |
| Rabotnik | Bitola | |
| Sloga | Skopje | |
| SSK Skopje | Skopje | |
| Tikvesh | Kavadarci |
Karovski, Ilija (1996) FK Tikvesh 1930–1995 p. 35, 36