| Competition: | League of Ireland |
| Season: | 1950–51 |
| Winners: | Cork Athletic (2nd title) |
| League Topscorer: | Desmond Glynn (20 goals) |
| Matches: | 90 |
| Total Goals: | 337 |
| Prevseason: | 1949–50 |
| Nextseason: | 1951–52 |
The 1950–51 League of Ireland was the 30th season of senior football in the Republic of Ireland.
Cork Athletic were the defending champions.
No new teams were elected to the League.
Cork Athletic successfully defended their title.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Dessie Glynn | Drumcondra | 20 |
| 2 | Johnny Vaughan | Cork Athletic | 14 |
| 3 | Martin Colfer | Shelbourne | 10 |
| 3 | Pat Gallacher | Dundalk | 10 |
| 3 | George Gray | Sligo Rovers | 10 |
| 6 | Tommy Carberry | Shelbourne | 9 |
| 7 | Christy Boggan | Shamrock Rovers | 8 |
| 7 | Leo McDonagh | Dundalk | 8 |
| 7 | Joe Martin | Dundalk | 8 |
| 10 | Paddy Cronin | Cork Athletic | 7 |