| Team: | Chicago Cardinals |
| Year: | 1949 |
| Record: | 6–5–1 |
| Division Place: | 3rd NFL Western |
| Coach: | Phil Handler, Buddy Parker |
| Stadium: | Comiskey Park |
| Radio: | WGN |
| Playoffs: | Did not qualify |
| Shortnavlink: | Cardinals seasons |
The 1949 Chicago Cardinals season was the franchise's 30th season in the National Football League. The Cardinals missed the postseason for the first time since 1946. This season was the last time the Cardinals beat the Green Bay Packers on the road until 2018.
| Week | Date | Opponent | Result | Record | Venue | |||
|---|---|---|---|---|---|---|---|---|
| 1 | Washington Redskins | W 38–7 | 1–0 | Comiskey Park | ||||
| 2 | October 2 | Chicago Bears | L 7–17 | 1–1 | Comiskey Park | |||
| 3 | at Philadelphia Eagles | L 3–28 | 1–2 | Shibe Park | ||||
| 4 | October 16 | at Green Bay Packers | W 39–17 | 2–2 | Wisconsin State Fair Park | |||
| 5 | October 23 | Detroit Lions | L 7–24 | 2–3 | Comiskey Park | |||
| 6 | October 30 | New York Giants | L 38–41 | 2–4 | Comiskey Park | |||
| 7 | November 6 | at Detroit Lions | W 42–19 | 3–4 | Briggs Stadium | |||
| 8 | November 13 | at New York Bulldogs | W 65–20 | 4–4 | Polo Grounds | |||
| 9 | November 20 | Los Angeles Rams | T 28–28 | 4–4–1 | Comiskey Park | |||
| 10 | November 27 | Green Bay Packers | W 41–21 | 5–4–1 | Comiskey Park | |||
| 11 | December 4 | at Los Angeles Rams | W 31–27 | 6–4–1 | Los Angeles Memorial Coliseum | |||
| 12 | December 11 | at Chicago Bears | L 21–52 | 6–5–1 | Wrigley Field | |||
| Note: Intra-division opponents are in bold text. | ||||||||