| Competition: | Serie A |
| Season: | 1949–50 |
| Size: | 280px |
| Winners: | Juventus 8th title |
| Relegated: | Bari Venezia |
| League Topscorer: | Gunnar Nordahl (35 goals) |
| Matches: | 380 |
| Total Goals: | 1265 |
| Prevseason: | 1948–49 |
| Nextseason: | 1950–51 |
The 1949–50 Serie A season was won by Juventus.
Como and Venezia had been promoted from Serie B.
| Rank | Player | Club | Goals | |
|---|---|---|---|---|
| 1 |  Gunnar Nordahl | Milan | 35 | |
| 2 | István Nyers | Internazionale | 30 | |
| 3 | John Hansen | Juventus | 28 | |
| 4 |  Benjamin Santos | Torino | 27 | |
| 5 |  Alberto Galassi | Fiorentina | 23 | |
| 6 | Renzo Burini | Milan | 22 | |
| 7 | Giampiero Boniperti | Juventus | 20 | |
| Amedeo Amadei | Internazionale | |||
| 9 | Giancarlo Vitali | Padova | 19 | |
| Mihály Kincses | Lucchese | |||
| 11 | Gunnar Gren | Milan | 18 | |
| Nils Liedholm | Milan | |||
| Karl Aage Hansen | Atalanta | |||
| Vittorio Ghiandi | Como | |||
| Rinaldo Martino | Juventus | |||
| Adriano Bassetto | Sampdoria | |||
| 17 | Jørgen Leschly Sørensen | Atalanta | 17 | |
| 18 | Faas Wilkes | Internazionale | 16 |