| Season: | 1949–50 |
| Competition: | Maltese First Division |
| Winners: | Floriana F.C. (13th title) |
| Relegated: | Birkirkara F.C. |
| Matches: | 56 |
| Total Goals: | 194 |
| Prevseason: | 1948–49 |
| Nextseason: | 1950–51 |
The 1949–50 Maltese First Division was the 35th season of top-tier football in Malta. It was contested by 8 teams, and Floriana F.C. won the championship.