| Competition: | League of Ireland |
| Season: | 1949–50 |
| Winners: | Cork Athletic (1st title) |
| League Topscorer: | David McCulloch (19 goals) |
| Biggest Home Win: | Dundalk 5–0 Transport Shamrock Rovers 7–2 Bohemians Cork Athletic 8-3 Limerick |
| Biggest Away Win: | Shamrock Rovers 2–5 Cork Athletic |
| Highest Scoring: | Cork Athletic 8–3 Limerick |
| Matches: | 90 |
| Total Goals: | 316 |
| Prevseason: | 1948–49 |
| Nextseason: | 1950–51 |
The 1949–50 League of Ireland was the 29th season of senior football in the Republic of Ireland.
No new teams were elected to the League.
Cork Athletic won their first title.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | David McCulloch | Waterford | 19 |
| 2 | Patrick O'Leary | Cork Athletic | 13 |
| 3 | Johnny Vaughan | 12 | |
| 4 | Bobby Duffy | Shamrock Rovers | 11 |
| 5 | Jimmy Duggan | Transport | 9 |
| Dessie Glynn | Drumcondra | ||
| 7 | Austin Curtin | Waterford | 8 |
| Sam Waters | Sligo Rovers | ||
| 9 | Joe Ralph | Dundalk | 7 |
| 10 | Dan Lavery | 6 | |
| Jackie O'Reilly | Cork Athletic | ||