| Election Name: | 1948 United States Senate election in Wyoming |
| Country: | Wyoming |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1942 United States Senate election in Wyoming |
| Previous Year: | 1942 |
| Next Election: | 1954 United States Senate elections in Wyoming |
| Next Year: | 1954 |
| Election Date: | November 2, 1948 |
| Image1: | Lester Hunt.jpg |
| Nominee1: | Lester C. Hunt |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 57,953 |
| Percentage1: | 57.11% |
| Nominee2: | Edward V. Robertson |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 43,527 |
| Percentage2: | 42.89% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Election: | Edward V. Robertson |
| Before Party: | Republican Party (United States) |
| After Election: | Lester C. Hunt |
| After Party: | Democratic Party (United States) |
The 1948 United States Senate election in Wyoming was held on November 2, 1948. First-term Republican Senator Edward V. Robertson ran for re-election to a second term. He was challenged in the general election by Democrat Lester C. Hunt, the Governor of Wyoming. Aided in part by President Harry S. Truman's narrow victory in Wyoming over Republican Thomas E. Dewey, and with his own record of winning statewide in Wyoming, Hunt defeated Robertson in a landslide. However, Hunt would not serve a full term in the Senate; he died by suicide on June 19, 1954 and Republican Edward D. Crippa was appointed to replace him. As of 2023, this was the last time an incumbent Senator from Wyoming lost re-election for this seat.