| Election Name: | 1948 United States Senate election in Kentucky |
| Country: | Kentucky |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1946 United States Senate special election in Kentucky |
| Previous Year: | 1946 (special) |
| Next Election: | 1952 United States Senate special election in Kentucky |
| Next Year: | 1952 (special) |
| Election Date: | November 2, 1948 |
| Nominee1: | Virgil Chapman |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 408,256 |
| Percentage1: | 51.39% |
| Nominee2: | John Sherman Cooper |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 383,776 |
| Percentage2: | 48.31% |
| Map Size: | 300px |
| U.S. Senator | |
| Before Election: | John Sherman Cooper |
| Before Party: | Republican Party (United States) |
| After Election: | Virgil Chapman |
| After Party: | Democratic Party (United States) |
The 1948 United States Senate election in Kentucky took place on November 2, 1948. Incumbent Republican Senator John Sherman Cooper, who won a 1946 special election to fill the vacant seat of Commissioner of Baseball Happy Chandler, ran for a full term in office but was defeated by Democratic U.S. Representative Virgil Chapman.