| Election Name: | 1948 United States Senate election in Iowa |
| Country: | Iowa |
| Flag Image: | Flag of Iowa (xrmap collection).svg |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1942 United States Senate election in Iowa |
| Previous Year: | 1942 |
| Next Election: | 1954 United States Senate election in Iowa |
| Next Year: | 1954 |
| Election Date: | November 2, 1948 |
| Image1: | File:Guy Mark Gillette.jpg |
| Nominee1: | Guy Gillette |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 578,226 |
| Percentage1: | 57.80% |
| Nominee2: | George A. Wilson |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 415,778 |
| Percentage2: | 41.56% |
| Map Size: | 220px |
| U.S. Senator | |
| Before Election: | George A. Wilson |
| Before Party: | Republican Party (United States) |
| After Election: | Guy Gillette |
| After Party: | Democratic Party (United States) |
The 1948 United States Senate election in Iowa took place on November 2, 1948. Incumbent Republican Senator George A. Wilson ran for re-election to a second term but was defeated by Democratic former Senator Guy Gillette.