| Election Name: | 1948 United States Senate election in Colorado |
| Country: | Colorado |
| Flag Year: | 1911 |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1942 United States Senate election in Colorado |
| Previous Year: | 1942 |
| Next Election: | 1954 United States Senate election in Colorado |
| Next Year: | 1954 |
| Election Date: | November 2, 1948 |
| Image1: | Edwin Johnson.jpg |
| Nominee1: | Ed Johnson |
| Party1: | Democratic Party (US) |
| Popular Vote1: | 340,719 |
| Percentage1: | 66.79% |
| Party2: | Republican Party (US) |
| Popular Vote2: | 165,059 |
| Percentage2: | 32.36% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Party: | Democratic Party (US) |
| After Party: | Democratic Party (US) |
The 1948 United States Senate election in Colorado took place on November 2, 1948. Incumbent Democratic Senator Edwin C. Johnson was re-elected to third term in a landslide over Republican Will Nicholson, a businessman and Air Force veteran, winning every county in the state.
Johnson outperformed fellow Democrat Harry S. Truman in the concurrent presidential election by 29%. As of 2023, this is the last time that an incumbent Democratic Senator from Colorado was re-elected or won re-election for this seat.