| Year: | 1948 |
| Team: | Mississippi Southern Southerners |
| Sport: | football |
| Conference: | Gulf States Conference |
| Short Conf: | GSC |
| Record: | 7–3 |
| Conf Record: | 4–0 |
| Head Coach: | Reed Green |
| Hc Year: | 9th |
| Stadium: | Faulkner Field |
| Champion: | GSC champion |
The 1948 Mississippi Southern Southerners football team was an American football team that represented Mississippi Southern College (now known as the University of Southern Mississippi) as a member of the Gulf States Conference during the 1948 college football season. In their ninth year under head coach Reed Green, the team compiled a 7–3 record.
Mississippi Southern was ranked at No. 108 in the final Litkenhous Difference by Score System ratings for 1948.[1]