| Season: | 1948–49 |
| Competition: | Maltese First Division |
| Winners: | Sliema Wanderers F.C. (12th title) |
| Relegated: | Naxxar Lions |
| Matches: | 57 |
| Total Goals: | 209 |
| Prevseason: | 1947–48 |
| Nextseason: | 1949–50 |
The 1948–49 Maltese First Division was the 34th season of top-tier football in Malta. It was contested by 8 teams, and Sliema Wanderers F.C. won the championship.
The team managed to gain the top of the leaderboard only on the penultimate day, after winning by 1-0 a decisive clash against the historical rivals of Floriana.[1]
With both St. George's and Naxxar Lions level on 6 points, a play-off match was conducted to determine 8th place and the relegation.