| Year: | 1946 |
| Team: | Wayne Tartars |
| Sport: | football |
| Conference: | Mid-America Conference |
| Short Conf: | MAC |
| Record: | 4–5 |
| Conf Record: | 0–1 |
| Head Coach: | John P. Hackett |
| Hc Year: | 1st |
The 1946 Wayne Tartars football team represented Wayne University (later renamed Wayne State University) in the Mid-America Conference (MAC) during the 1946 college football season. Under first-year head coach John P. Hackett, the team compiled a 4–5 record.[1]