| Election Name: | 1946 United States Senate election in Ohio |
| Country: | Ohio |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1940 United States Senate election in Ohio |
| Previous Year: | 1940 |
| Next Election: | 1952 United States Senate election in Ohio |
| Next Year: | 1952 |
| Election Date: | November 5, 1946 |
| Image1: | File:John W. Bricker cph.3b31299.jpg |
| Nominee1: | John W. Bricker |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 1,275,774 |
| Percentage1: | 57.02% |
| Nominee2: | James W. Huffman |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 947,610 |
| Percentage2: | 42.36% |
| U.S. Senator | |
| Before Election: | James W. Huffman |
| Before Party: | Democratic Party (United States) |
| After Election: | John W. Bricker |
| After Party: | Republican Party (United States) |
The 1946 United States Senate elections in Ohio was held on November 5, 1946, alongside a concurrent special election to the same seat.
Former Republican Governor of Ohio and 1944 nominee for the U.S. vice presidency John W. Bricker defeated Democratic interim senator James W. Huffman, who had been appointed to fill the vacant seat left by Supreme Court Justice Harold Hitz Burton. In a concurrent special election to finish Burton's unexpired term, Republican Kingsley Taft defeated Henry P. Webber.
Incumbent Senator Harold Hitz Burton resigned from office in October 1945 to accept a seat on the United States Supreme Court. Governor Frank Lausche appointed James W. Huffman to fill Burton's vacant seat until a successor could be duly elected. The special election to fill the seat was scheduled for November 5, 1946, concurrent with the election to the next full term.
Huffman did not run in the special election, but ran in the election for the full term beginning in 1947.