| Election Name: | 1946 United States Senate election in Pennsylvania |
| Country: | Pennsylvania |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1940 United States Senate election in Pennsylvania |
| Previous Year: | 1940 |
| Next Election: | 1952 United States Senate election in Pennsylvania |
| Next Year: | 1952 |
| Election Date: | November 5, 1946 |
| Image1: | EdwardMartinPA.jpg |
| Nominee1: | Edward Martin |
| Party1: | Republican Party (US) |
| Popular Vote1: | 1,853,458 |
| Percentage1: | 59.26% |
| Nominee2: | Joseph F. Guffey |
| Party2: | Democratic Party (US) |
| Popular Vote2: | 1,245,338 |
| Percentage2: | 39.81% |
| Map Size: | 260px |
| U.S. Senator | |
| Before Election: | Joseph F. Guffey |
| Before Party: | Democratic Party (US) |
| After Election: | Edward Martin |
| After Party: | Republican Party (US) |
The 1946 United States Senate election in Pennsylvania was held on November 5, 1946. Incumbent Democratic U.S. Senator Joseph F. Guffey sought re-election to another term, but was defeated by Republican nominee Edward Martin. This was the last time that the Republican candidate won Philadelphia in an election for the Class 1 Senate seat.
|-|-bgcolor="#EEEEEE"| colspan="3" align="right" | Totals| align="right" | 3,127,860| align="right" | 100.00%| align="right" | |}