| Election Name: | 1946 United States Senate election in Nebraska |
| Country: | Nebraska |
| Flag Year: | 1925 |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1940 United States Senate election in Nebraska |
| Previous Year: | 1940 |
| Next Election: | 1952 United States Senate election in Nebraska |
| Next Year: | 1952 |
| Election Date: | November 5, 1946 |
| Image1: | BUTLER, Hugh Alfred,.jpg |
| Nominee1: | Hugh A. Butler |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 271,208 |
| Percentage1: | 70.82% |
| Nominee2: | John E. Mekota |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 111,751 |
| Percentage2: | 29.18% |
| Map Size: | 300px |
| U.S. Senator | |
| Before Party: | Republican Party (US) |
| After Party: | Republican Party (US) |
The 1946 United States Senate election in Nebraska took place on November 5, 1946. The incumbent Senator, Hugh A. Butler, was re-elected to a second term in a landslide, defeating John E. Mekota.