| Election Name: | 1946 United States Senate election in Missouri |
| Country: | Missouri |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1940 United States Senate election in Missouri |
| Previous Year: | 1940 |
| Next Election: | 1952 United States Senate election in Missouri |
| Next Year: | 1952 |
| Election Date: | November 5, 1946 |
| Image1: | File:Jamespkem.jpg |
| Nominee1: | James P. Kem |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 572,556 |
| Percentage1: | 52.71% |
| Nominee2: | Frank P. Briggs |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 511,544 |
| Percentage2: | 47.09% |
| Map Size: | 270px |
| U.S. Senator | |
| Before Election: | Frank P. Briggs |
| Before Party: | Democratic Party (United States) |
| After Election: | James P. Kem |
| After Party: | Republican Party (United States) |
The 1946 United States Senate election in Missouri was held on November 5, 1946.
Incumbent Democratic Senator Frank P. Briggs, who was appointed to fill the vacancy left by President Harry S. Truman, ran for election to a full term in office, but was defeated by Republican James Kem.