| Election Name: | 1946 United States Senate election in Minnesota |
| Country: | Minnesota |
| Flag Year: | 1893 |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1940 United States Senate election in Minnesota |
| Previous Year: | 1940 |
| Next Election: | 1952 United States Senate election in Minnesota |
| Next Year: | 1952 |
| Election Date: | November 5, 1946 |
| Image1: | EdwardThye.jpg |
| Nominee1: | Edward J. Thye |
| Party1: | Republican Party of Minnesota |
| Popular Vote1: | 517,775 |
| Percentage1: | 58.92% |
| Nominee2: | Theodore Jorgenson |
| Party2: | Minnesota Democratic–Farmer–Labor Party |
| Popular Vote2: | 349,520 |
| Percentage2: | 39.78% |
| Map Size: | 270px |
| U.S. Senator | |
| Before Election: | Henrik Shipstead |
| Before Party: | Republican Party of Minnesota |
| After Election: | Edward J. Thye |
| After Party: | Republican Party of Minnesota |
The 1946 United States Senate election in Minnesota took place on November 5, 1946. It was the first election to either of Minnesota's seats in the United States Senate held since the Minnesota Democratic Party and the Farmer-Labor Party of Minnesota merged in 1944, to form the Minnesota Democratic-Farmer-Labor Party. Incumbent U.S. Senator Henrik Shipstead was defeated in the Republican primary by Governor Edward John Thye, who went on to defeat DFL challenger Theodore Jorgenson in the general election.