| Election Name: | 1946 United States Senate election in Indiana |
| Country: | Indiana |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1940 United States Senate election in Indiana |
| Previous Year: | 1940 |
| Next Election: | 1952 United States Senate election in Indiana |
| Next Year: | 1952 |
| Election Date: | November 5, 1946 |
| Image1: | File:WilliamJenner (cropped).jpg |
| Nominee1: | William E. Jenner |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 739,807 |
| Percentage1: | 54.91% |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 584,288 |
| Percentage2: | 43.36% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Party: | Republican Party (United States) |
| After Party: | Republican Party (United States) |
The 1946 United States Senate election in Indiana took place on November 5, 1946. Incumbent Republican U.S. Senator Raymond E. Willis did not run for re-election. Former interim Senator William E. Jenner was elected over Governor of Indiana M. Clifford Townsend.