| Year: | 1946 |
| Team: | Eastern Illinois Panthers |
| Sport: | football |
| Conference: | Illinois Intercollegiate Athletic Conference |
| Short Conf: | IIAC |
| Record: | 2–6 |
| Conf Record: | 1–3 |
| Head Coach: | Maynard O'Brien |
| Hc Year: | 1st |
| Stadium: | Schahrer Field |
The 1946 Eastern Illinois Panthers football team represented Eastern Illinois University as a member of the Illinois Intercollegiate Athletic Conference (IIAC) during the 1946 college football season. The team was led by first-year head coach Maynard O'Brien and played their home games at Schahrer Field in Charleston, Illinois. The Panthers finished the season with a 2–6 record overall and a 1–3 record in conference play.[1]