| Year: | 1946 |
| Team: | Colorado Buffaloes |
| Sport: | football |
| Conference: | Mountain States Conference |
| Short Conf: | MSC |
| Record: | 5–4–1 |
| Conf Record: | 3–2–1 |
| Head Coach: | James J. Yeager |
| Hc Year: | 4th |
| Captain: | Gus Shannon |
| Stadium: | Folsom Field |
The 1946 Colorado Buffaloes football team was an American football team that represented the University of Colorado as a member of the Mountain States Conference (MSC) during the 1946 college football season. In their fourth season under head coach James J. Yeager, the Buffaloes compiled a 5–4–1 record (3–2–1 against MSC opponents), finishing tied for fourth place in the MSC. They were outscored by a total of 147 to 91.
End John Zisch and guard Gus Shannon were selected by the International News Service as first-team players on the 1946 All-Mountain States football team. Center Dean was named to the second team.[1]
The 1947 NFL draft was held on December 16, 1946. The following Buffaloes were selected.[5]
| 21 | 190 | Bob West | Back | Green Bay Packers | |
| 22 | 202 | Maurice "Tex" Reilly | Back | Green Bay Packers |