| Season: | 1945 |
| Manager: | Joreca |
| Mgrtitle: | Manager |
| Chairman: |  Décio Pacheco Pedroso |
| Chrtitle: | Chairman |
| League: | Torneio Rio-São Paulo |
| Cup1: | Campeonato Paulista |
| Cup1 Result: | Champions |
| Prevseason: | 1944 |
| Nextseason: | 1946 |
The 1945 football season was São Paulo's 16th season since the club's founding in 1930.
| Games played | 42 (20 Campeonato Paulista, 22 Friendly match) |
| Games won | 26 (16 Campeonato Paulista, 10 Friendly match) |
| Games drawn | 8 (2 Campeonato Paulista, 6 Friendly match) |
| Games lost | 8 (2 Campeonato Paulista, 6 Friendly match) |
| Goals scored | 136 |
| Goals conceded | 62 |
| Goal difference | +74 |
| Best result | 12–1 (H) v Jabaquara - Campeonato Paulista - 1945.07.08 |
| Worst result | 2–6 (A) v Olimpia - Friendly match - 1945.10.12 |
| Most appearances | |
| Top scorer | |