| Competition: | Peruvian Segunda División |
| Season: | 1945 |
| Dates: | 23 December 1945 – 13 January 1946 |
| Winners: | Santiago Barranco |
| Prevseason: | 1944 |
| Nextseason: | 1946 |
The 1945 Peruvian Segunda División, the second division of Peruvian football (soccer), was played by 6 teams. The tournament winner, Santiago Barranco was promoted to the Promotional Playoff. Association Chorrillos and Unión Callao was promoted to the 1946 Peruvian Segunda División. The league table is incomplete.
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