| Competition: | Primera División |
| Season: | 1945 |
| Winners: | River Plate (8th title) |
| Promoted: | Gimnasia y Esgrima (LP) |
| Relegated: | Gimnasia y Esgrima (LP) |
| Continentalcup1: | 1945 Copa Aldao |
| Continentalcup1 Qualifiers: | River Plate |
| League Topscorer: |  Angel Labruna (25 goals) |
| Prevseason: | 1944 |
| Nextseason: | 1946 |
The 1945 Argentine Primera División was the 54th season of top-flight football in Argentina. The season began on April 22 and ended on December 2.[1]
Gimnasia y Esgrima (LP) returned to Primera but the squad would be relegated again at the end of the season, after finishing last. River Plate won its 8th title.