| Election Name: | 1944 United States Senate election in Oklahoma |
| Country: | Oklahoma |
| Flag Year: | 1941 |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1938 United States Senate election in Oklahoma |
| Previous Year: | 1938 |
| Next Election: | 1950 United States Senate election in Oklahoma |
| Next Year: | 1950 |
| Election Date: | November 7, 1944 |
| Image1: | File:Oklahoma Senator. Washington, D.C., April 19, 1939 A new informal picture of Senator Elmer Thomas, Democrat of Oklahoma LCCN2016875466 (cropped).jpg |
| Nominee1: | Elmer Thomas |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 390,851 |
| Percentage1: | 55.65% |
| Nominee2: | William J. Otjen |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 309,222 |
| Percentage2: | 44.02% |
| U.S. Senator | |
| Before Election: | Elmer Thomas |
| Before Party: | Democratic Party (United States) |
| After Election: | Elmer Thomas |
| After Party: | Democratic Party (United States) |
The 1944 United States Senate election in Oklahoma took place on November 7, 1944. Incumbent Democratic Senator Elmer Thomas ran for re-election to a fourth term. Thomas once again faced a stiff challenge in the Democratic primary, this time from Congressman Wesley E. Disney and Lieutenant Governor James E. Berry. As was the case in 1938, Thomas won renomination only with a narrow plurality. In the general election, he faced former State Senator William J. Otjen, the 1942 Republican nominee for Governor. Though Thomas's performance was much reduced compared to six years prior, he still defeated Otjen by a wide margin.